Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses
نویسندگان
چکیده
منابع مشابه
CNVs: Harbingers of a Rare Variant Revolution in Psychiatric Genetics
The genetic bases of neuropsychiatric disorders are beginning to yield to scientific inquiry. Genome-wide studies of copy number variation (CNV) have given rise to a new understanding of disease etiology, bringing rare variants to the forefront. A proportion of risk for schizophrenia, bipolar disorder, and autism can be explained by rare mutations. Such alleles arise by de novo mutation in the ...
متن کاملthe relationship between efl learners linguistic and logical intelligence and the frequency and types of informal fallacies and evidence in argumentative writing
مطالعه حاضر با هدف بررسی وجود رابطه ی ممکن میان هوشهای زبانی و منطقی زبان آموزان انگلیسی و تعداد و انواع مغلطه های زبانی و شواهد در متنهای استدلالی آنان انجام پذیرفته است.بدین منظور، 70 زبان آموز با سطح زبانی متوسط به بالا از دو موسسه زبان انگلیسی در ایران انتخاب شده و پرسشنامه های مزبوطه را تکمیل نموده و متنی استدلالی نوشتند. متون نوشته شده مورد بررسی قرار گرفته و نمرات پرسشنامه ها محاسبه شده ...
15 صفحه اولReflections on the relationship between psychiatric genetics and psychiatric nosology.
Research advances in psychiatric genetics have raised expectations that genetic findings might lead to major breakthroughs in psychiatric nosology. The author reviews the plausibility of these claims. Four areas are addressed. First, it is argued that familial aggregation of a single putative psychiatric syndrome provides at best limited evidence for the validity of that syndrome. Second, both ...
متن کاملSimilarity between hypotheses and evidence.
We explore two novel consequences of similarity-based likelihood judgment. In Section I, we distinguish between the evidence on which judgments are based and the hypotheses that serve as the objects of judgment. The location of a feature, whether in the evidence or the hypotheses, influences the perceived similarity between evidence and hypotheses and consequently yields judgments that are inco...
متن کاملGenetics in psychiatry: common variant association studies
Many psychiatric conditions and traits are associated with significant heritability. Genetic risk for psychiatric conditions encompass rare variants, identified due to major effect, as well as common variants, the latter analyzed by association analyses. We review guidelines for common variant association analyses, undertaking after assessing evidence of heritability. We highlight the importanc...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2011
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2011.65